Endocrine Abstracts

Introduction: Wernicke Encephalopathy (WE) is an acute neurologic disorder caused by thiamine deficiency. It is characterized by the classic triad of encephalopathy, gait ataxia and oculomotor dysfunction. It occurs in the setting of poor nutrition caused by lack of dietary intake or malabsorption. Since both of them can happen in patients that underwent bariatric surgery it is of utmost importance to prevent, recognize and treat this severe complication.<p class="abstext"...

Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration and bleeding. Electrochemotherapy (ECT) is a minimally invasive oncologic treatment of tumours located in the skin and subcutaneous tissue. The electric pulses potentiates the toxicity of a cytostatic agent entering the tumour cell. It is highly effective especially to relieve pain and improve quality of life. The adverse events are local and transient. A case of progressive metasta...

Background: PCOS is a common female endocrine disorder, exacerbated by obesity. International guidelines therefore suggest weight loss as first line management. This service evaluation assessed the care pathway of patients referred to Queen Elizabeth Hospital Birmingham (QEHB) with suspected PCOS. We aimed to assess the referral wait time, reason for referral, treatment offered, and weight management in clinic.Methods: We undertook a cross-sectional stud...

Background: Ectopic ACTH syndrome (EAS) is rare and published series are scarce.Aim: To increase the understanding of EAS we describe 31 consecutive cases in years 1997–2016.Results: Of the 31 patients, 65% (20/31) were women and 35% (11/31) men. Median follow-up was 23 months (0–217). Median age at diagnosis was 62 years (21–78), with peak incidences in age groups 30–39 and 60–69 years. Most patients prese...

Introduction: A form of ACTH-dependent Cushing syndrome is an ectopic production of ACTH. The aetiology can by benign lesion or a malignant non-pituitary tumor, which is more common. The prevalence of endogenous Cushing syndrome is 1 in 26 000. Ectopic ACTH secretion is responsible for 7–15% of the cases. Principal position of the ACTH-producing tumor is in lungs – a bronchial endocrine tumor and small cell lung cancer. Small peripheral bronchial carcinoids can easil...

Background: It is well known that many nuerohormonal and genetic factors influence on the developing of obesity in children. Serotoninergic system is determined to be one of the most important factors. Serotonin may induce lipogenesis or triacylglycerol synthesis in the liver and/or white adipose tissue.Aim: To establish interactions between serotoninergic system and metabolic parameters in obese children.Methods: We examined 280 c...

Background: Transition is an important stage in the care of a young person with a long-term endocrine condition.Objective: To explore current services for young people (YP) with endocrine conditions from the perspective of paediatric and adult endocrinologists, and YP and their parents using their services.Methods: There were two components:- i). service questionnaire for completion by paediatric and adult endocrinologists ii). &#1...

Aim: To evaluate the recovery rate, characteristics and factors that might help predict the HPA axis recovery of patients with glomerulonephritis (GN) and GC-induced AI.Study Design: A retrospective study involving all GN patients referred from January 2014-December 2016 with a confirmed diagnosis of GC-induced AI with a planned weaning from conventional Prednisolone (Pred) immunosuppression and switch onto Hydrocortisone (HC). Data collected up to Novem...

Introduction: Skin tags (acrochordons) are a recognised feature of insulin resistance, but the extent to which they predict an adverse metabolic profile or the response to lifestyle modification in severely obese adults is not known.Aims: We sought to quantify prospectively differences in anthropometric and metabolic characteristics in severely obese adults with acrochordons vs those without acrochordons, and to determine whether the presence of acrochor...

Carney complex (CNC) is rare autosomal dominant disorder, which was firstly described as a combination of manifestation of myxomas, spotty skin pigmentation and endocrine overactivity in 1985. This condition affects many organs and varies in clinical manifestation. The presence of at least two clinical signs is considered as pathognomonic with regard to a sporadic form of CNC, and an evidence of at least one sign with simultaneous manifestation of CNC in any of first degree re...